Frederick S Kaplan Selected Research

Inborn Genetic Diseases (Disease, Hereditary)

1/2022	Clearance of Senescent Cells From Injured Muscle Abrogates Heterotopic Ossification in Mouse Models of Fibrodysplasia Ossificans Progressiva.
1/2021	Dysregulated BMP signaling through ACVR1 impairs digit joint development in fibrodysplasia ossificans progressiva (FOP).
1/2019	Fibrodysplasia Ossificans Progressiva (FOP): A Segmental Progeroid Syndrome.
1/2018	Depletion of Mast Cells and Macrophages Impairs Heterotopic Ossification in an Acvr1R206H Mouse Model of Fibrodysplasia Ossificans Progressiva.
7/2017	The congenital great toe malformation of fibrodysplasia ossificans progressiva? - A close call.
11/2016	ACVR1-Fc suppresses BMP signaling and chondro-osseous differentiation in an in vitro model of Fibrodysplasia ossificans progressiva.
12/2012	CNS demyelination in fibrodysplasia ossificans progressiva.
1/2012	Functional analysis of alleged NOGGIN mutation G92E disproves its pathogenic relevance.
11/2011	Fibrodysplasia ossificans progressiva: a blueprint for metamorphosis.
11/2011	Heterozygous inactivation of Gnas in adipose-derived mesenchymal progenitor cells enhances osteoblast differentiation and promotes heterotopic ossification.

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Frederick S Kaplan Research Topics

Disease

46	Myositis Ossificans (Fibrodysplasia Ossificans Progressiva) 01/2022 - 01/2003
22	Heterotopic Ossification (Ectopic Ossification) 01/2022 - 09/2003
16	Inborn Genetic Diseases (Disease, Hereditary) 01/2022 - 04/2003
6	Inflammation (Inflammations) 01/2022 - 01/2003
3	Progressive Osseous Heteroplasia 01/2018 - 04/2003
2	Osteochondrodysplasias (Spondyloepiphyseal Dysplasia) 11/2020 - 01/2010
2	Wounds and Injuries (Trauma) 02/2014 - 11/2005
1	Hypoxia (Hypoxemia) 01/2022
1	Premature Aging 01/2022
1	Fever (Fevers) 06/2021
1	Leiomyoma (Uterine Fibroids) 06/2021
1	Sepsis (Septicemia) 06/2021
1	Cardiac Arrhythmias (Arrythmia) 01/2020
1	Congenital Abnormalities (Deformity) 01/2018
1	Cytomegalovirus Infections (Inclusion Disease) 01/2018
1	Pain (Aches) 01/2018
1	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 01/2018
1	Brachydactyly 07/2017
1	Hallux Valgus 07/2017
1	Ankylosis 02/2014
1	Type B1 Brachydactyly 01/2012
1	Fatigue 12/2011
1	Soft Tissue Injuries (Soft Tissue Injury) 12/2011
1	Edema (Dropsy) 12/2011
1	Virus Diseases (Viral Diseases) 12/2011
1	Osteochondroma (Osteocartilaginous Exostosis) 02/2008
1	Neoplasms (Cancer) 02/2008
1	Pseudohypoparathyroidism 05/2007
1	Disease Progression 02/2007
1	Aplastic Anemia (Anemia, Hypoplastic) 02/2007
1	Heart Valve Diseases (Valvular Heart Disease) 03/2005
1	Paresis (Hemiparesis) 04/2003

Drug/Important Bio-Agent (IBA)

30	Bone Morphogenetic Proteins (Bone Morphogenetic Protein)IBA 01/2022 - 04/2003
14	Type I Bone Morphogenetic Protein ReceptorsIBA 01/2022 - 05/2006
8	Activin Receptors (Activin Receptor)IBA 11/2020 - 01/2008
6	Phosphotransferases (Kinase)IBA 01/2022 - 03/2009
6	activin AIBA 01/2022 - 02/2008
6	Activins (Activin)IBA 01/2022 - 05/2007
6	Proteins (Proteins, Gene)FDA Link 01/2020 - 03/2003
5	Bone Morphogenetic Protein ReceptorsIBA 01/2021 - 05/2014
5	Glycine (Aminoacetic Acid)FDA LinkGeneric 06/2012 - 09/2007
5	Serine (L-Serine)FDA Link 06/2012 - 09/2007
3	Pharmaceutical PreparationsIBA 01/2018 - 10/2009
3	GTP-Binding Proteins (G-Protein)IBA 11/2011 - 04/2003
3	Adenylyl Cyclases (Adenylyl Cyclase)IBA 11/2011 - 04/2003
2	Biomarkers (Surrogate Marker)IBA 01/2022 - 01/2018
2	Codon (Codons)IBA 01/2022 - 05/2008
2	Imatinib Mesylate (Gleevec)FDA Link 01/2021 - 01/2018
2	PalovaroteneIBA 01/2018 - 01/2016
2	DNA (Deoxyribonucleic Acid)IBA 01/2018 - 04/2003
2	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2018 - 12/2011
2	Bone Morphogenetic Protein 4IBA 04/2007 - 03/2004
2	RNA (Ribonucleic Acid)IBA 04/2003 - 03/2003
1	TenascinIBA 01/2022
1	AdiponectinIBA 01/2022
1	Kallikreins (Kallikrein)IBA 01/2022
1	Ion Channels (Ion Channel)IBA 01/2020
1	Aprepitant (Emend)FDA Link 01/2018
1	Tyrosine Kinase InhibitorsIBA 01/2018
1	Retinoic Acid Receptor gammaIBA 01/2018
1	Cromolyn Sodium (Cromoglicic Acid)FDA LinkGeneric 01/2018
1	Prednisone (Sone)FDA LinkGeneric 01/2018
1	Tretinoin (Retinoic Acid)FDA LinkGeneric 01/2018
1	Sirolimus (Rapamycin)FDA Link 01/2018
1	Oxygen (Dioxygen)IBA 01/2016
1	Amino Acids FDA Link 01/2012
1	Substance PIBA 10/2011
1	matrigelIBA 03/2009
1	CardiotoxinsIBA 03/2009
1	NucleotidesIBA 05/2008
1	Heparan Sulfate Proteoglycans (Heparan Sulfate Proteoglycan)IBA 12/2007
1	Lysine (L-Lysine)FDA Link 09/2007
1	SaltsIBA 09/2007
1	Aspartic Acid (Aspartate)FDA Link 09/2007
1	LigandsIBA 09/2007
1	Histidine (L-Histidine)FDA Link 09/2007
1	Hormones (Hormone)IBA 05/2007
1	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 03/2005
1	Transcription Factors (Transcription Factor)IBA 09/2003
1	Explosive Agents (Explosives)IBA 09/2003
1	RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA 04/2003
1	chordinIBA 04/2003
1	FollistatinIBA 04/2003
1	Messenger RNA (mRNA)IBA 04/2003
1	NF-kappa B (NF-kB)IBA 01/2003

Therapy/Procedure

5	Therapeutics 01/2018 - 05/2007
3	Intramuscular Injections 12/2011 - 11/2005
1	Hysterectomy 06/2021
1	Salpingectomy 06/2021
1	Liver Transplantation 01/2018
1	Anesthesia 02/2014
1	General Anesthesia 02/2014
1	Airway Management 02/2014
1	Prenatal Care (Care, Prenatal) 01/2010
1	Transplantation 02/2007
1	Bone Marrow Transplantation (Transplantation, Bone Marrow) 02/2007
1	Operative Surgical Procedures 11/2005